21-hydroxysteroid dehydrogenase (NADP+)

In enzymology, a 21-hydroxysteroid dehydrogenase (NADP ) (EC 1.1.1.151) is an enzyme that catalyzes the chemical reaction

pregnan-21-ol NADP ${\displaystyle \rightleftharpoons }$ pregnan-21-al NADPH H

Thus, the two substrates of this enzyme are pregnan-21-ol and NADP , whereas its 3 products are pregnan-21-al, NADPH, and H .

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NADP 21-oxidoreductase. Other names in common use include 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), dehydrogenase, 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide, phosphate), NADP -21-hydroxysteroid dehydrogenase, and 21-hydroxysteroid dehydrogenase (NADP ).

References

• Monder C, White A (1965). "The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases". J. Biol. Chem. 240: 71–7. PMID 14253469.